MONOCLONAL ANTI-STRUMPELLIN ANTIBODY

Code: SAB4200647-100UL D2-231

Application

Monoclonal Anti-Strumpellin antibody has been used in immunoblotting immunoprecipitation flow cytometry

Biochem/physiol Actions

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€557.00 100UL
€685.11 inc. VAT

Application

Monoclonal Anti-Strumpellin antibody has been used in immunoblotting immunoprecipitation flow cytometry

Biochem/physiol Actions

Strumpellin, causes hereditary spastic paraplegia, a progressive neurodegenerative disorder clinically characterized by central motor system deficits leading to spastic paraparesis of the lower limbs. Strumpellin presence was observed in protein aggregate diseases affecting striated muscles and the Central nervous system (CNS).

KIAA0196 (strumpellin) is involved in the WASH (WASP and Scar homologue) complex, an actin-regulating complex. It works as an interlink between actin regulation and endosomal membrane dynamics. Mutations in KIAA0196 are associated with spastic paraplegia and RSS (Ritscher-Schinzel syndrome).

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

The gene KIAA0196 (strumpellin) is mapped to human chromosome 8q24. It is a widely expressed gene and the protein localizes in the cytoplasm and endoplasmic reticulum.

Monoclonal Anti-Strumpellin (mouse IgG1 isotype) is derived from the hybridoma St-1 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a synthetic peptide corresponding to an internal region of human Strumpellin, conjugated to KLH.

Immunogen

synthetic peptide corresponding to an internal region of human Strumpellin.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

antibody formpurified immunoglobulin
antibody product typeprimary antibodies
biological sourcemouse
cloneSt-1, monoclonal
concentration~1 mg/mL
formbuffered aqueous solution
Gene Informationhuman ... KIAA0196(9897)
isotypeIgG1
mol wtantigen ~120 kDa
Quality Level200
shipped indry ice
species reactivitymouse, human, rat
storage temp.−20°C
technique(s)immunoprecipitation (IP): 5-10 µg using using lysates of rat A10 cells., flow cytometry: 10-20 µg/test using using HeLa cells., immunoblotting: 2.5-5 µg/mL
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